Recent advances in the treatment of complex congenital diaphragmatic hernia—a narrative review

Background and Objective: Congenital diaphragmatic hernia (CDH) is an anomaly of the cardiopulmonary system maturation process that results from both a global embryopathy concomitant mechanical compression abdominal contents during fetal maturation. This in pulmonary hypertension, hypoplasia, cardiac dysfunction, requiring intense critical care management. The patients with highest risk CDH are most challenging, resource-intensive, bear mortality. Advances at basic, translational, clinical research levels leading to novel therapies management strategies for complex, high-risk CDH. Our objective review approaches thinking complex patients. These include prenatal postnatal indicators defects, those receiving extracorporeal life support (ECLS), anomalies such as and/or chromosomal abnormalities.